Detalles de la búsqueda
1.
Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.
Lancet
; 403(10428): 741-755, 2024 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38342126
2.
Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea.
Sex Transm Infect
; 99(1): 64-69, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36411033
3.
In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes.
Antimicrob Agents Chemother
; 66(2): e0216521, 2022 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34930028
4.
Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections.
Antimicrob Agents Chemother
; 66(3): e0149221, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34978887
5.
Antimicrobial Resistance Trends in Urine Escherichia coli Isolates From Adult and Adolescent Females in the United States From 2011 to 2019: Rising ESBL Strains and Impact on Patient Management.
Clin Infect Dis
; 73(11): 1992-1999, 2021 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34143881
6.
Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems.
Antimicrob Agents Chemother
; 65(12): e0012221, 2021 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34543096
7.
Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944).
BMC Microbiol
; 21(1): 181, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34130619
8.
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis).
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32284384
9.
Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model.
Antimicrob Agents Chemother
; 64(10)2020 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32661002
10.
In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31818823
11.
Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.
Euro Surveill
; 25(43)2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33124551
12.
Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation.
Clin Infect Dis
; 67(4): 504-512, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29617982
13.
Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30249694
14.
Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226.
Antimicrob Agents Chemother
; 60(7): 4404-6, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27161642
15.
Correction to: Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK2140944).
BMC Microbiol
; 21(1): 293, 2021 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34702186
16.
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
Antimicrob Agents Chemother
; 59(1): 289-98, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25348524
17.
Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent.
J Clin Microbiol
; 52(7): 2629-32, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24759716
18.
A randomized, double-blind, comparative study to assess the safety and efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of secondarily infected traumatic lesions and impetigo due to methicillin-resistant Staphylococcus aureus.
Adv Skin Wound Care
; 27(12): 548-59, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25396674
19.
Prevalence, regional distribution, and trends of antimicrobial resistance among female outpatients with urine Klebsiella spp. isolates: a multicenter evaluation in the United States between 2011 and 2019.
Antimicrob Resist Infect Control
; 13(1): 21, 2024 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38355621
20.
Analysis of the effect of urine on the in vitro activity of gepotidacin and levofloxacin against Escherichia coli, Staphylococcus epidermidis, and Staphylococcus saprophyticus.
Diagn Microbiol Infect Dis
; 106(3): 115946, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37201401